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Thursday, June 2, 2011
Mesothelioma Screening Using Plasma Samples May Increase Accuracy of Diagnosis
Biomarkers are one of the most relevant tools for the early diagnosis of mesothelioma. Although the cancer is typically not detected until its later stages, new screening tests look for the presence of these proteins in a patient’s blood or tissue samples to detect mesothelioma.To evaluate the diagnostic accuracy of these tests, an Australian study explored the sensitivity of two blood-based biomarkers, mesothelin and osteopontin, in blood serum and plasma samples from 176 patients. The results showed that plasma samples provided a more accurate biomarker reading than blood serum samples collected from the same patient.To measure the sensitivity of the biomarker content in blood serum and plasma levels, researchers from the National Research Centre for Asbestos Related Diseases at the ...
Spice Extract May Induce Death of Mesothelioma Cells
Curcumin, a derivative of the spice turmeric, has come into the medical spotlight as a potential agent in treating mesothelioma. Recent in vitro and in vivo studies have investigated the turmeric-based compound’s ability to induce apoptosis, or programmed cell death. Curcumin has also been studied in conjunction with chemotherapy drugs to measure its affect on the impact of chemotherapeutic treatment.Malignant mesothelioma, which develops in the linings of certain internal organs, frequently alters cell cycles and apoptosis pathways. This makes the cells very difficult to kill via chemotherapy or radiation therapy. As a result, strategies to make the cells more responsive to treatment are a major focus of mesothelioma research.After observing biological and molecular responses by malig...
Novel handheld PET probes provide intraoperative localization of PET-avid lymph nodes
Conclusions This novel tool may be used synergistically with the PET scan examination to maximize intraoperative nodal selection and sampling. Content Type Journal ArticlePages 1-8DOI 10.1007/s00464-011-1696-zAuthorsSegundo J. González, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USAJoyce Wong, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USALorena González, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USAPeter Brader, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USAMaureen Zakowski, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USAMithat Gönen, Department of Epidemiology and Biostatisti...
Wednesday, June 1, 2011
Pathology of the Pleura: What the Pulmonologists Need to Know
AbstractPrimary and metastatic pleural neoplasms, and non-neoplastic pleural diseases, can have similar clinical, radiographic, and gross features. However, treatments and prognoses of these diverse pleural conditions vary greatly. Accurate diagnosis of pleural disease is therefore extremely important; and histologic interpretation of pleural biopsies is vital to rendering an accurate diagnosis. Smaller biopsies contribute to the difficulties in accurately characterizing pleural lesions; and immunostains are frequently employed in their assessment. Diffuse malignant mesothelioma, the most common primary pulmonary neoplasm, is rare; however, other less common primary pleural neoplasms, including solitary fibrous tumor, the most common benign primary pleural neoplasm, occur. These neoplasm...
Novel Anti-Mesothelioma Strategy
A drug commonly used to treat kidney cancer may increase the effectiveness of chemotherapy for mesothelioma, according to a study published in the May issue of the Journal of Thoracic Oncology. Temsirolimus, a kinase inhibitor, blocks the action of mammalian target of rapamycin (mTOR), a protein that regulates cell growth, which can slow tumor growth. It's used to treat advanced renal cell carcinoma. But researchers in Austria have found that temsirolimus also may slow the growth of malignant pleural mesothelioma cells... (Source: Health News from Medical News Today)
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